It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.
Anavar, or oxandrolone, is one of the only true fat-burning steroids out there today. It is incredibly popular among bodybuilders and athletes during their cutting cycles, and because it is incredibly anabolic in nature, using it can help preserve your gains while burning pure body fat. Anavar alone does not cause the fat loss; it simply makes the process more efficient than diet and exercise alone. For men, a dose of 40mg to 50mg per day is sufficient; women should use 10mg to 15mg per day at most. Anavar cycles for fat loss usually run in two to four-week bursts with small breaks in between for as long as necessary to achieve the desired results.