“Mr. Dubanovich sustained carbon monoxide poisoning and anoxic brain injury [in a 2007 house fire],” Long said in the letter. “… Mr. Dubanovich has been participating in outpatient rehabilitation… dealing with a combination of issues from traumatic brain injury (TBI) rehabilitation, cognitive rehabilitation, post-traumatic stress disorder… in recovery from opiate addiction… breathing problems… sleep apnea… Hepatitis C [treatment]… counseling for depression and anxiety.”
Flutamide and 2-hydroxyflutamide have been found in vitro to inhibit CYP17A1 (17α-hydroxylase/17,20-lyase), an enzyme which is required for the biosynthesis of androgens.  In accordance, flutamide has been found to slightly but significantly lower androgen levels in GnRH analogue-treated male prostate cancer patients  and women with polycystic ovary syndrome .  As such, flutamide is a weak inhibitor of androgen biosynthesis.  However, the clinical significance of this action may be limited when flutamide is given without a GnRH analogue to non-castrated men, as the drug markedly elevates testosterone levels into the high normal male range via prevention of AR activation-mediated negative feedback on the hypothalamic–pituitary–gonadal axis in this context.