Oxymetholone is without a doubt the strongest and most visibly active steroid to date. Not only does it act very rapidly, it causes a virtual explosion of mass. Gains of up to 10 pounds in 2 weeks are not uncommon. This is largely due to a moderate to low androgenic effect combined with a high anabolic activity also mediated by non-AR mechanisms (mechanisms other than simply binding the androgen receptor). You can imagine that the gains made on oxymetholone aren't the leanest. You would note a drastic smoothing out of the muscle due to estrogen-related fat (lipolysis) and water retention. This lipolysis has been shown to be rather drastic. One study1 on long-term hemodialysis patients showed beyond a doubt the role that oxymetholone can play in causing hyperlipedemia. The fat deposition rate, post-hepatic (after processing by the liver), increased drastically in the oxymetholone group while numbers remained stable in the control group.
The use of anabolic steroids will suppress natural testosterone. The rate of suppression is dependent on the steroid in question, but in the case of Oxymetholone it is enough to warrant the use of exogenous testosterone. This will actually hold true with most anabolic steroids. Those who supplement with Anadrol and forgo exogenous testosterone therapy will fall into a low testosterone condition. Not only is this a condition that comes with numerous bothersome symptoms, it is an extremely unhealthy state. The form of testosterone you choose when using Anadrol is of no consequence, however, you should ensure you are applying enough to provide what the body needs.
Once the use of Anadrol and all anabolic steroids has come to an end and all the exogenous hormones have cleared your system natural testosterone production will begin again. This is assuming there was no prior existing low level state. It also assumes no damage was done to the HPTA during supplementation due to improper practices. While natural testosterone production will begin again on its own, it will not be fast. It is generally recommended that the individual begin a Post Cycle Therapy (PCT) treatment plan following anabolic steroid use . This will encourage natural testosterone production and speed the healing process up. It will not automatically return you to your previous natural high level on its own; that will take some time. However, it will ensure you have enough testosterone in your body to function properly while your levels continue to naturally rise.